Degenerative meniskrupturer bør ikke opereres
نویسندگان
چکیده
منابع مشابه
Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKe
IKKe and TBK1 are noncanonical IKK family members which regulate inflammatory signaling pathways and also play important roles in oncogenesis. However, few inhibitors of these kinases have been identified. While the substrate specificity of IKKe has recently been described, the substrate specificity of TBK1 is unknown, hindering the development of high-throughput screening technologies for inhi...
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Viral infection or TLR3 engagement causes activation of the transcription factors IRF-3 and NF-jB, which collaborate to induce transcription of type I IFN genes. IKKe and TBK1 are two IKK-related kinases critically involved in virusand TLR3-triggered activation of IRF-3. We identified a protein termed SIKE (for Suppressor of IKKe) that interacts with IKKe and TBK1. SIKE is associated with TBK1 ...
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Canine degenerative myelopathy (DM) is an adult-onset fatal neurodegenerative disease that occurs in many breeds. The initial upper motor neuron spastic paraparesis and general proprioceptive ataxia in the pelvic limbs progress to a flaccid lower motor neuron tetraparesis. Recently, a missense mutation in the superoxide dismutase 1 (SOD1) gene was found to be a risk factor for DM, suggesting th...
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Osteoporosis has become a major medical problem as the aged population of the world rapidly grows. Osteoporosis predisposes patients to fracture, progressive spinal deformities, and stenosis, and is subject to be a major concern before performing spine surgery, especially with bone fusions and instrumentation. Osteoporosis has often been considered a contraindication for spinal surgery, while i...
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Osteoporosis has become a major medical problem as the aged population of the world rapidly grows. Osteoporosispredisposes patients to fracture, progressive spinal deformities, and stenosis, and is subject to be a major concernbefore performing spine surgery, especially with bone fusions and instrumentation. Osteoporosis has often beenconsidered a contraindication for spinal surgery, while in s...
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ژورنال
عنوان ژورنال: Tidsskrift for Den norske legeforening
سال: 2017
ISSN: 0029-2001
DOI: 10.4045/tidsskr.16.1028